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α2-Macroglobulin, 5 mg
Product Description
α2-Macroglobulin
Application Notes
α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.Usage Statement
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Key Applications
Inhibitor
Specifications
| SKU | 0219134505 |
| Alternate Names | α2-M;α2-Macroglobulin |
| Application Notes | α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor. |
| Base Catalog Number | 19134505 |
| Biochemical Physiological Actions | One mg of α2-macroglobulin will inhibit a minimum of 10 μg trypsin with an activity of 10,000 BAEE un/mg protein. α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation. |
| CAS # | Not applicable |
| Format | Crystalline powder |
| Formulation Details | Lyophilized from 490 µL 30 mM Na phosphate; pH 7.0 and 10 mg Glucine and 1 mg glycine. |
| Pack Size | 5 mg |
| Purity | ≥95% (SDS-PAGE) |
| Source | Human plasma |
| Usage Statement | Research Use Only (RUO). Ready for CE IVD labeling of clinical applications. |
Documents
Certificates of Analysis
Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)