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α2-Macroglobulin, 5 mg

α2-Macroglobulin, 5 mg

$762.55
α2-Macroglobulin

SKU: 0219134505

Synonyms
α2-M;α2-Macroglobulin
CAS Number:
Not applicable
MDL Number:
MFCD00130472
Packaging size:
5 mg
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Product Description
α2-Macroglobulin

Application Notes

α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibitor

Specifications
SKU 0219134505
Alternate Names α2-M;α2-Macroglobulin
Application Notes α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.
Base Catalog Number 19134505
Biochemical Physiological Actions One mg of α2-macroglobulin will inhibit a minimum of 10 μg trypsin with an activity of 10,000 BAEE un/mg protein. α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
CAS # Not applicable
Format Crystalline powder
Formulation Details Lyophilized from 490 µL 30 mM Na phosphate; pH 7.0 and 10 mg Glucine and 1 mg glycine.
Pack Size 5 mg
Purity ≥95% (SDS-PAGE)
Source Human plasma
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)