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Aprotinin

Aprotinin

Synonyms Pancreatic Basic Trypsin Inhibitor, polypeptide; Antagosan; Antikrein; Trasylol; Zymofren; Trypsin inhibitor (basic); Antilysin(e); BPTI; Bayer A 128; Kallikrein-trypsin inactivator; Fosten; Iniprol; Kunitz protease inhibitor; Onquinin; Repulson; RP-9921; Ryker 52G; Triazinin

CAS Number: 9087-70-1 Molecular Formula: C284H432N84O79S7 Molecular Weight: 6511.509 g/mol

EC Number: 232-994-9 MDL Number: MFCD00130541

SKU 02194559-CF
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Description

Product Description

Aprotinin

Application Notes

It is used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Serine protease inhibitor

Specifications
SKU 02194559-CF
Alternate Names Pancreatic Basic Trypsin Inhibitor, polypeptide; Antagosan; Antikrein; Trasylol; Zymofren; Trypsin inhibitor (basic); Antilysin(e); BPTI; Bayer A 128; Kallikrein-trypsin inactivator; Fosten; Iniprol; Kunitz protease inhibitor; Onquinin; Repulson; RP-9921; Ryker 52G; Triazinin
Application Notes It is used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Base Catalog Number 194559
Biochemical Physiological Actions Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3.
CAS # 9087-70-1
EC Number 232-994-9
Extinction Coefficient E1% (280 nm) = 8.3 (water)(Lit.)
Format Powder
Grade Cell Culture Grade
Isoelectric Point 10.5(Lit.)
Melting Point >100 °C
Molecular Formula C284H432N84O79S7
Molecular Weight 6511.509 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
RTECS Number YN5080000
Source Bovine Lung
Specific Activity ~4 inhibitor u/mg
Sterilization of Solutions Sterilization of solutions can be done by filtration through a 0.2 µm filter.
Typical Working Concentration Effective Concentration is Equimolar with protease (1-2 µg/mL).
Unit Definition One Kallikrein Inactivating Unit is the quantity of protease inhibitor that has the ability to inhibit 2 Kallikrein units by 50% under optimal conditions.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λ max (water) : 277 ± 5 nm