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β2-Microglobulin, 500 µg

β2-Microglobulin, 500 µg

$431.35
β2-Microglobulin

SKU: 02153903.5

Synonyms
β2-Microglobulin; β2-M
CAS Number:
Not applicable
MDL Number:
MFCD00130615
Packaging size:
500 µg
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Product Description
β2-Microglobulin

Application Notes

To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Stability of the MHC antigens

Specifications
SKU 02153903.5
Alternate Names β2-Microglobulin; β2-M
Application Notes To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.
Base Catalog Number 153903.5
Biochemical Physiological Actions A transient complex of MHC heavy chain and β2-Microglobulin is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-Microglobulin complex to the cell surface. Absence of binding leads to degradation in the proteasome.
CAS # Not applicable
Format Solid
Formulation Details Lyophilized from 0.02 M NH4(HCO3)
Pack Size 500 µg
Purity 30 - 60 %
Source Human Urine
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)