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Canine anti-globulin (Coombs' test) reagent, 5 mL

Canine anti-globulin (Coombs' test) reagent, 5 mL

$517.45

Key features and details

The anti-globulin or Coombs' test is widely used to detect the presence of antibody in the diagnosis of autoimmune hemolytic anemia.

SKU: 08646351

Packaging size:
5 mL
Product Description

The anti-globulin or Coombs' test is widely used to detect the presence of antibody in the diagnosis of autoimmune hemolytic anemia. Antibody alone or in the presence of complement injures the cell membrane permitting leakage of RBC material, allowing recognition by the reticuloendothelial cells, thereby leading to phagocytosis and destruction of RBC's. Anti-globulin reagent (Coombs' serum) is prepared by immunizing rabbits with canine IgG, IgM and C3 purified from normal serum. The resulting whole antiserum is heat treated to inactivate complement and is adsorbed with normal pooled canine erythrocytes to remove nonspecific agglutinins.

Application Notes

Canine anti-globulin or Coombs' test is widely used to detect the presence of antibody in the diagnosis of autoimmune hemolytic anemia. Antibody alone or in the presence of complement injures the cell membrane permitting leakage of RBC material, allowing recognition by the reticuloendothelial cells, thereby leading to phagocytosis and destruction of RBC's. Immune mediated erythrocyte destruction is also seen in canine systemic lupus erythematosus some infections and in neoplastic disorders.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Immunoassays | Autoimmune Hemolytic Anemia (AIHA) diagnosis

Documents

Datasheet

Datasheet

Material Safety Datasheet

Material Safety Datasheet
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Specifications
SKU 08646351
Antibody Type Polyclonal Antibody
Application Notes Canine anti-globulin or Coombs' test is widely used to detect the presence of antibody in the diagnosis of autoimmune hemolytic anemia. Antibody alone or in the presence of complement injures the cell membrane permitting leakage of RBC material, allowing recognition by the reticuloendothelial cells, thereby leading to phagocytosis and destruction of RBC's. Immune mediated erythrocyte destruction is also seen in canine systemic lupus erythematosus some infections and in neoplastic disorders.
Base Catalog Number 646351
Conjugate Unconjugated
Disease Screened Autoimmune hemolytic anemia (AIHA)
Formulation Details Lyophilized
Host Rabbit
Pack Size 5 mL
Preparation Method Anti-globulin reagent (Coombs' serum) is prepared by immunizing rabbits with canine IgG, IgM and C3 purified from normal serum. The resulting whole antiserum is heat treated to inactivate complement and is adsorbed with normal pooled canine erythrocytes to remove nonspecific agglutinins. Canine anti-globulin reagent is presented in lyophilized form. One mL of reconstituted material is sufficient for 10 tests by the tube method or 50 when using the microtiter plate method.
Solubility Soluble in water
Species Reactivity Dog
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.