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Hemin chloride, molecular biology reagent,≥95%, 1 g
Product Description
Hemin Chloride
Application Notes
Hemin chloride, at a concentration of 20 mM demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. In the rat Hemin chloride has been noted to stimulate calcium dependent K+ channels along with control of fluid transport and Na+ in the loop of henle. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes Hemin chloride demonstrated anti-apoptotic, anti-inflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-kappa B, Hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare certain types of Agar medium for the cultivation of distinct bacteria. Hemin was used to study conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis.
Usage Statement
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Key Applications
Stimulate calcium dependent K+ channels
Documents
Datasheet
Datasheet
Specifications
| SKU | 0219402501 |
| Alternate Names | Hemin Chloride; Chloroferriprotoporphyrin; Chlorohemin; Chloro(protoprophyrinato) iron (III); Ferriprotoporphyrin IX chloride; Hematin hydrochloride; Protohemin IX; (SP-5-13)-Chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N21, N22, N23, N24] ferrate(2-) dihydrogen; Chloro [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2, 18-porphinedipropionato (2-)]iron; 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7- dipropionic acid ferrichloride; Teichmann's crystals; Ferriheme chloride; Chloroprotoporphyrin IX iron(III) |
| Application Notes | Hemin chloride, at a concentration of 20 mM demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. In the rat Hemin chloride has been noted to stimulate calcium dependent K+ channels along with control of fluid transport and Na+ in the loop of henle. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes Hemin chloride demonstrated anti-apoptotic, anti-inflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-kappa B, Hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare certain types of Agar medium for the cultivation of distinct bacteria. Hemin was used to study conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis. |
| Base Catalog Number | 19402501 |
| Beilstein Registry Number | 5229914 |
| CAS # | 16009-13-5 |
| EC Number | 240-140-1 |
| Format | Powder |
| Grade | Molecular Biology Grade |
| Molecular Formula | C34H32ClFeN4O4 |
| Pack Size | 1 g |
| Personal Protective Equipment | Eyeshields, Gloves, Respirator filter |
| Preparation Method | Typically prepared by heating a hemoglobin solution with acetic acid and sodium chloride. |
| Purity | ≥95% |
| Source | Bovine |
| Usage Statement | Research Use Only (RUO). Ready for CE IVD labeling of clinical applications. |
| UV Visible Absorbance | λ max (0.1N NaOH): 380 - 387 nm |
Citations