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Leupeptin Hydrochloride is used in immunoblotting and acts as a Protease inhibitor.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Immunoblotting | Protease Inhibitor
|Alternate Names||Acetyl-Leu-Leu-Arg-al hydrochloride|
|Application Notes||Leupeptin Hydrochloride is used in immunoblotting and acts as a Protease inhibitor.|
|Base Catalog Number||195624|
|Biochemical Physiological Actions||Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)|
|Molecular Weight||463.02 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Typical Working Concentration||Effective concentration is typically 10-100 uM.|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|