Enjoy 30% off select life science products with free shipping and giveaways with promo code: RESEARCH30 Offer ends October 2, 2020.
Application NotesRifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Antibiotic | Inhibitor of transcription initiation | Antipruritic agent
|Alternate Names||Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin;|
|Application Notes||Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.|
|Base Catalog Number||19479581|
|Beilstein Registry Number||5723476|
|Biochemical Physiological Actions||Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. It Inhibits the assembly of DNA and protein into mature virus particles.|
|Extinction Coefficient||EmM (max absorbance, phosphate buffer,pH 7.38): 33.20 (237 nm); 32.10 (255 nm); 27.00 (334 nm);15.40 (475 nm)(Lit.)|
|Grade||molecular biology reagent, γ-irradiated|
|Isoelectric Point||4.8(in water)(Lit.)|
|Optical Rotation||[α]D25°=+10.6° (c=0.5% in CDCl3)(Lit.)|
|Pack Size||150 mg|
|Personal Protective Equipment||Dust mask, Eyeshields, Gloves|
|pKa||pKa (in water):1.7 (4-hydroxyl group), 7.9 (4-piperazine nitrogen); in methylcellosolve-water (4:1): 3.6 (4-hydroxyl group), 6.7 (3-piperazine nitrogen)(Lit.)|
|UV Visible Absorbance||λ max, methanol: 237 - 239 nm|